Radim Černý (CZ)
European Research Infrastructures: Find your collaboration partner in structural biology and chemical biology
Modern biological projects are complex and often require access to a variety of different state-of-the-art technologies, which are not always available to researchers. European Research Infrastructures are publically funded, not-for-profit organisations which support scientists to implement their projects by providing access to cutting-edge technology platforms and expertise. Find out how you can benefit from services provided by Instruct-ERIC and EU-OPENSCREEN, and hear two interesting examples of recent research from leading scientists using these technologies:
Zn-dependent nucleases from plants, fungi and bacterial pathogens
3′-nucleases/nucleotidases of the S1-P1 family participate in a wide variety of biological processes and have many biotechnological applications. They take a variety of roles across living organisms but are missing in mammals. Dr Jan Dohnálek will describe recent NMR based studies at the Instruct-ERIC centre showing specific properties of the plant enzyme with anticancerogenic properties, new mechanistic insights on the fungal representative and the key properties of the enzyme from Legionella pneumophila.
Dr Jan Dohnálek, Group leader at Biotechnology and Biomedicine Center of the Academy of Sciences and Charles University in Vestec (BIOCEV), Czech Republic.
Biological space exploration using small molecule probes
Chemical probes are indispensable tools in modern biology commonly used to study gene function, validate molecular targets or dissect complex processes within cells and organisms. Yet, identifying probes that meet all the demands of an experimental design is not a trivial task. Dr Petr Bartunek will describe recent in-silico approaches available at EU-OPENSCREEN, and their applications in academic drug discovery efforts including drug repurposing and high-throughput combinatorial approaches to guide the biologist to select appropriate high-quality probes for their experiments.
Dr Petr Bartunek, Director CZ-OPENSCREEN, National Infrastructure for Chemical Biology; and Group leader at Institute of Molecular Genetics at Academy of Sciences, Prague, Czech Republic
Naomi Gray, EU Scientific Project Manager, Instruct, UK. email@example.com
Bahne Stechmann, Scientific Manager, EU-OPENSCREEN, FMP Leibniz-Institute for Molecular Pharmacology, Berlin, Germany. firstname.lastname@example.org